Deuterohemin-ala-his-thr-val-glu-lys (DhHP-6) is a new type of synthetic oxidase-mimicking enzyme, has antioxidant effects and the ability to scavenge free radicals. It also has the potential to act as an antioxidant enzyme. In this study, an oxidative stress model of human gingival fibroblasts (HGFs) in vitro and a rat periodontitis model in vivo were established to study the antioxidant effect of DhHP-6 and its mechanism, the inflammatory response of periodontitis, and the protective effect of DhHP-6 on alveolar bone resorption induced by periodontitis. DhHP-6 reduced oxidative stress and the expression of inflammatory factors in HGFs. DhHP-6 had a dose-dependent protective effect on alveolar bone absorption in rats with periodontitis, enhanced rat antioxidant capacity and reduced inflammation. Micro-CT scanning showed that DhHP-6 reduced alveolar bone loss and improved the bone structure of the left maxillary first molar of rats. HE staining results showed that, compared with the control, there were no obvious morphological and histological changes in the rat organs. These results suggest that DhHP-6 can be used to treat experimental periodontitis in rats by increasing the expression levels of antioxidant enzymes and antioxidants in systemic and local tissues, which reduces the content of oxidation products and cyto-inflammatory factors.
BACKGROUND
Amphetamine-Type Stimulants (ATS) stimulants are highly neurotoxic and can cause significant cognitive impairment and psychotic symptoms. They are characterized by strong mental dependence and severe consequences for abuse.
OBJECTIVE
Therefore, it is of great significance to systematically understand the treatment method of ATS on the human body, and to the treatment of ATS drugs dependent on compulsory isolation. This article focuses on the research of moderate-intensity aerobic exercise on the neurological rehabilitation of ATS-dependent drug dependence detoxification.
METHODS
This article uses a combination of quantitative and qualitative research methods to select eligible ATS abusers in the compulsory quarantine detoxification center in Baini Lake, Hunan Province, as the research object. Quantitative research uses the ATS questionnaire to survey new ATS abusers who meet the criteria.
RESULTS
Qualitative research uses focus group interviews and case interviews, uses purposeful sampling, and uses semi-structured interview outlines as tools to collect and process data. The results of quantitative and qualitative research complement each other to verify and analyze and discuss together. The results showed that the levels of oxidative stress in ATS dependent patients were significantly different from those in healthy subjects. After exercise intervention, the level of oxidative stress, blood routine, and psychological level of SAS and SDS were improved in the exercise group. The experimental results show that there are nerve damages in people who rely on ATS drugs for compulsory isolation and detoxification.
CONCLUSIONS
The damages tend to continue to increase after withdrawal. Furthermore, moderate-intensity aerobic exercise for 12 weeks can slow down the aggravation of nerve damages.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.