The influence of i.m. administration to the mother of hydrocortisone acetate (doses of 0.4, 0.8 or 2.0 mg/100 g body weight/day) during the first 15 days of lactation on milk protein and lactose composition and serum levels of protein, glucose and insulin in dams and pups is studied. Total serum proteins and albumin/globulin ratio in dams were unchanged by treatment. The daily injection of 0.4 or 0.8 mg/100 g body weight failed to alter serum levels of glucose or insulin in dams, whereas a dose of 2.0 mg/100 g body weight led to a rise in glucemia (from 118 +/- 3.2 to 133 +/- 5.3) which was accompanied by a sharp change in insulinemia (from 40.7 +/- 4.1 to 83.6 +/- 6.9). All three doses raised protein levels in milk. The smallest increase was recorded with 2.0 mg/100 g body weight; this dose also reduced milk lactose content. Total serum proteins in pups rose slightly but nonsignificantly, and no significant effects were noted on albumin/globulin ratio or serum glucose and insulin levels.
The influence of i.m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied. Serum levels of cholesterol and triglycerides in mothers increase at any of the experimental doses. Daily injections of 2 mg/100 g bw to the mother cause an increase in the percentage of C16 as well as in the level of fatty acids derived from linoleic and linolenic acids while reducing the percentage of C18:1. The treatment brings about a higher level in total lipids in the milk which is proportional to the dose. Doses of 0.4 and 0.8 mg increase the percentage of C8 and C10, while the dose of 2 mg enhances the % of C16. A fall in the uptake of linoleic acid by the mammary gland is observed when using any of the experimental doses. No change is observed either in the weight of pups or in serum cholesterol levels while triglyceride level is increased by the effect of treatment. The higher dose increases the level of linolenic acid and some of its derivates.
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