Objective: the main intention of this research is to prepare a curcumin based herbal gel sanitizer by minimizing the alcoholic usage and to evaluate the anti-bacterial activity of this herbal sanitizer. Methods: curcumin gel sanitizer was prepared from the ethanolic extract of Curcuma longa along with addition of gel base prepared from the combination of carbapol-940 and HPMC-E15. Results: The curcumin gel sanitizer was formulated and evaluated for its phytochemical constituents present in curcumin, detection of active constituent of curcumin which was majorly responsible for the anti-microbial activity through HPTLC, organoleptic properties, irritancy test and the efficiency of anti-bacterial activity of curcumin was also evaluated and it is safe and effective against pathogens. Conclusion: As a natural herb, curcumin which was a household ingredient could also be effectively formulated as a sanitizer that reduces the side effects of alcoholic sanitizer products and is a best source that acts effectively against a numerous pathogens. Keywords: curcumin, carbapol-940, Ethanolic extract, HPMC-E15 (hydroxypropyl methylcellulose), HPTLC, Pathogens,
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