KEYWORDSGlycerol-based SO3H-functionalized carbon catalyst was demonstrated as an efficient and recyclable green catalyst for the chemoselective synthesis of pentaerythritol diacetals with aromatic aldehydes in the presence of ketones in excellent yields in toluene at 80 C. In addition, the catalyst also has the capability for the deprotection of pentaerythritol diacetals in methanol at reflux temperature. The recovered catalyst without any pre-treatment was reused for 5 cycles without any deactivation and leaching into the reaction medium under optimum conditions. Reusability Chemoselectivity Aromatic aldehydes Pentaerythritol diacetals Glycerol-based SO3H-carbon catalyst Protection and deprotection of diacetals
A new series of isomannide monoundecenoate-based 1,2,3-triazole analogs 6a-e were designed by employing click chemistry in good yields. in vitro bioactive assay manifested that the several target compounds exhibited promising antibacterial and antifungal activities. Notably, compounds having phenyl substituted triazole 6a, and hydroxy phenyl substituted triazole 6b possessed highly selective promising inhibition towards Gram-positive bacterial strains namely Bacillus subtilis and Staphylococcus aureus with MIC value of 3.9 μg/ mL. Further, these potential hybrids (6a and 6b) also exhibited highly impressive antifungal activity against the tested panel of Candida strains with MIC value of 3.9 μg/mL. Based on our in vitro preliminary antimicrobial study, these two compounds 6a and 6b have been identified as potential antimicrobial lead compounds. Moreover, all prepared derivatives were also evaluated for their in vitro cytotoxic activities against A549, MCF7, DU145 and HeLa cancer cell lines. The results indicated that only the hydroxy phenyl substituted triazole analog 6b displayed good cytotoxic activity towards all tested human cancer cell lines without any significant effects on normal cell line (HUVEC).
KEYWORDSA series of β-hydroxyazides were effectively synthesized from the regioselective ring opening of oxiranes by azide anion in presence of glycerol-based sulfonic acid functionalized carbon as a novel reusable heterogeneous catalyst in H2O achieving good yields (80-98%). The workup procedure was simple, and the catalyst could be reused over five times without losing its catalytic activity and selectivity.Water Oxiranes Azidolysis Sodium azide Azidohydrins Carbon acid catalyst
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