The BLOODHOUND SSC project was publicly announced in October 2008, with a primary engineering objective of designing, constructing and running a vehicle capable of achieving a speed of 1000 mph on land. The aerodynamic design of this vehicle is to be accomplished using computational simulation only and this paper describes the development and application of the approach adopted. The computational model employs a cell vertex finite volume algorithm for the solution of compressible viscous flow problems on unstructured hybrid meshes. A one equation turbulence model is adopted and the solution of the steady flow equations is obtained by explicit relaxation. For the combination of high Mach number, complex geometry and complex boundary conditions, involving rotating surfaces and a rolling ground, a consistent HLLC numerical flux function is adopted to ensure a stable procedure. To illustrate the impact of the approach upon the final configuration, a number of simulations undertaken to aid the aerodynamic design are described.
Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Indeed, different MRI acquisitions provide different brain networks at the macroscale; whilst diffusion-weighted MRI (dMRI) provides a structural connectivity (SC) coincident with the bundles of parallel fibers between brain areas, functional MRI (fMRI) accounts for the variations in the blood-oxygenation-level-dependent T2* signal, providing functional connectivity (FC). Understanding the precise relation between FC and SC, that is, between brain dynamics and structure, is still a challenge for neuroscience. To investigate this problem, we acquired data at rest and built the corresponding SC (with matrix elements corresponding to the fiber number between brain areas) to be compared with FC connectivity matrices obtained by three different methods: directed dependencies by an exploratory version of structural equation modeling (eSEM), linear correlations (C) and partial correlations (PC). We also considered the possibility of using lagged correlations in time series; in particular, we compared a lagged version of eSEM and Granger causality (GC). Our results were two-fold: firstly, eSEM performance in correlating with SC was comparable to those obtained from C and PC, but eSEM (not C, nor PC) provides information about directionality of the functional interactions. Second, interactions on a time scale much smaller than the sampling time, captured by instantaneous connectivity methods, are much more related to SC than slow directed influences captured by the lagged analysis. Indeed the performance in correlating with SC was much worse for GC and for the lagged version of eSEM. We expect these results to supply further insights to the interplay between SC and functional patterns, an important issue in the study of brain physiology and function.
Alzheimer’s disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer’s Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G1 (N1 = 36, healthy control subjects, Control), G2 (N2 = 36, early mild cognitive impairment, EMCI), G3 (N3 = 36, late mild cognitive impairment, LMCI) and G4 (N4 = 36, AD). Diffusion-tensor brain networks were compared across three disease stages: stage I (Control vs. EMCI), stage II (Control vs. LMCI) and stage III (Control vs. AD). The group comparison was performed using the multivariate distance matrix regression analysis, a technique that was born in genomics and was recently proposed to handle brain functional networks, but here applied to diffusion-tensor data. The results were threefold: First, no significant differences were found in stage I. Second, significant differences were found in stage II in the connectivity pattern of a subnetwork strongly associated to memory function (including part of the hippocampus, amygdala, entorhinal cortex, fusiform gyrus, inferior and middle temporal gyrus, parahippocampal gyrus and temporal pole). Third, a widespread disconnection across the entire AD brain was found in stage III, affecting more strongly the same memory subnetwork appearing in stage II, plus the other new subnetworks, including the default mode network, medial visual network, frontoparietal regions and striatum. Our results are consistent with a scenario where progressive alterations of connectivity arise as the disease severity increases and provide the brain areas possibly involved in such a degenerative process. Further studies applying the same strategy to longitudinal data are needed to fully confirm this scenario.
Multiscale representation is a methodology that is being used more and more when describing real-world structures. Scale-space representation is one formulation of multiscale representation that has received considerable interest in the literature because of its efficiency in several practical applications and the distinct properties of the Gaussian kernel that generate the scale space. Together, some of these properties make the Gaussian unique. Unfortunately, the Gaussian kernel has two practical limitations: information loss caused by the unavoidable Gaussian truncation and the prohibitive processing time due to the mask size. We propose a new kernel family derived from the Gaussian with compact supports that are able to recover the information loss while drastically reducing processing time. This family preserves a great part of the useful Gaussian properties without contradicting the uniqueness of the Gaussian kernel. The construction and analysis of the properties of the proposed kernels are presented in this paper. To assess the developed theory, an application of extracting handwritten data from noisy document images is presented, including a qualitative comparison between the results obtained by the Gaussian and the proposed kernels.
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