Alternative and practical classes are effective in assisting teachers and students in the teaching-learning processes, aiming at good examples in the construction of knowledge, serving as a complement to traditional classes, which in most cases become exhausting due to lack of investment and innovation. The respiratory system is of great importance for human life as it is responsible for the absorption of oxygen through the airways and lungs. Observing the difficulties faced by teachers in the classroom due to limited resources within the school, this work had the objective of implementing an alternative methodology to improve the acquisition of knowledge about biophysics of the respiratory system. The research was carried out with a group of the 3rd year of High School of the Aluísio Germano School in the city of Carpina - PE. Two identical questionnaires were applied: one after the traditional class and another after the alternative class with the application of the Quiz game. The results indicated that there was a considerable increase in the correctness of the questions in the second questionnaire compared to the first one. In addition, it was observed that, during the class that used the game, the students showed more interest in knowing and learning about the subject, having an increase of interaction and totaling 85% the level of interaction in the proposed activities, which corroborates with other authors in the literature. In this way, it was noticeable that the use of playful resources associated with the practices can be great allies in the teaching-learning process.
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