Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced
by genetic, immunological, and environmental factors. We report the case of a
patient with psoriasis for more than 25 years who developed hyperuricemia and
chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may
occur by increased epidermal cell turnover, which accelerates purine metabolism
and has uric acid as the product of its catabolism. The association of psoriasis
with hyperuricemia can trigger the onset of gouty arthritis, and pose a greater
risk of developing other inflammatory comorbidities. Therefore, it is important
to periodically investigate uric acid levels in order to treat changes triggered
by hyperuricemia.
Rosacea fulminans or pyoderma faciale is a rare cutaneous disorder that usually
affects women usually between the ages of 15-46. The disease is characterized by
sudden onset of papules, pustules, cysts, and painful coalescing nodules with
red-cyanotic centrofacial erythema. Although its etiology remains unknown,
hormonal, immunological, and vascular factors have been reported. Early
diagnosis and prompt treatment should minimize unsightly scars. We report a case
of a 33-year-old female patient treated with traditional doses of doxycycline,
with improvement of the lesions and regression of the condition in two
months.
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