As an emerging type of important macrocycles for supramolecular chemistry, pillararenes and their derivatives have been widely studied and applied in numerous fields, which intensively promotes the development of chemistry, materials science and biology. Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results. Owing to easy preparation, reliable guest affinity, good biocompatibility and stability, pillararenes are frequently used to construct functional biomaterials. On one hand, pillararenes can either be used individually or form diversiform self-assemblies such as micelles, nanoparticles and vesicles to increase water solubility and biocompatibility of drugs. On the other hand, it is promising to modify solid materials like framework materials, silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability. In this review, we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy, photodynamic/photothermal therapy, antimicrobials, bioimaging, etc. By introducing several typical examples, the design principles, preparation strategies, identifications and bio-applications of these pillararene-based supramolecular systems are described. Future challenges and directions of this field are also outlined.
The
construction of smart nanomaterials from host macrocycles that
are responsive to specific stimuli has gained significant attention
in recent years. The application of pillar[n]arenes
has been of particular interest given their ease of functionalization
and tunability of the intrinsic cavity electronic properties that
allows them to encapsulate a great variety of guests and complex with
metal ions with high selectivity via noncovalent interactions, endowing
them with captivating properties and functions. Herein, we present
the most recent advances in the design and functionalization of pillar[n]arene-based smart nanomaterials, and their applications
for sensing, catalysis, drug delivery, and artificial transmembrane
channels.
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