Efficient one-pot, three components procedure to prepare new αamino phosphonate and phosphonic acid acyclic nucleosides An efficient one-pot three-component Kabachnick-Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethylphosphite proceeded for the synthesis of amino phosphonates using natural phosphate coated with iodine (I 2 @NP) as a catalyst. The novel α-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities.The molecular docking showed that the non-activity of these compounds may be is due to the absence of hydrophobic pharmacophores.
Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.
The one-step synthesis of several alpha-L-arabino and beta-L- xylonucleosides was performed in good yields under mild conditions by N-glycosylation of 1-O-acetyl-L-arabino and -xylofuranose using Vorbruggen type reaction conditions with or without Microwave irradiation.
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