Our research group is focused on determining the potential applications of using x‐ray diffraction signals to diagnosis breast cancer. We have built a custom made x‐ray diffractometer system. Polyenergetic 50 kV beams collimated down to a 3 mm diameter are incident on 5 mm diameter 5 mm thick samples. A cadmium zinc telluride detector is positioned at an angle θ with respect to the center of the target. We use our semianalytic model coupled with energy dispersive x‐ray diffraction measurements to extract differential linear scattering coefficients in units of m−1 sr−1. We optimize our system with H2normalO as our target since good x‐ray diffraction data is available. A 2‐mm diameter aperture is positioned in front of our detector and the target to detector distance is ≈ 40 cm. We use a root‐mean‐square deviation to measure the overall agreement between our data and the gold standard. We get values of 1.6 and 2.0 m−1 sr−1 for scatter angles of 13° and 16° and values of 3.4, 2.5, 2.1, 2.8, 1.8 m−1 sr−1 for angles 5, 7, 8, 9, and 11. These values are obtained after correcting our data for fluorescence escape and hole tailing. However, the values are nearly the same even if we don't correct the data. At this stage, more optimization is required. Our preliminary results for breast tissue agree well with data measured by Kidane et al., Phys. Med. Biol. 44, 1791–1802 (1999). We intend to correlate the x‐ray diffraction and cellular pathology signals of breast tissue.
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