A pulse radiolytic study using the cyclic tetrameric Schiff base N-coordinated copper complex Cu(TAAB) 2+ has been performed. The reaction of the Cu(TAAB) z+ complex with superoxide revealed pseudo first-order characteristics with the rate constant of k2 = (2.9 _+ 0.5) • 108 mol-i s-e din3. The complex survived the presence of competing serum albumin in physiological concentrations. The complex stability constant K = 1.15 x l0 ts (log K = 18.06) is two orders of magnitude higher than that of Cu(ll)-serum albumin (log K = 16.2). Transient changes of the stability during the oxidation/reduction process and in the presence of 600 pmol I-t albumin did not affect significantly either the electronic absorption of the complex or its catalytic activity.
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