days/year that were previously lost due to migraine, resulting in a positive ROI of 510%. In addition to ROI and work productivity gained, participants also gained on average 13.6 migraine-free days/year for their private and social life. Conclusions: This analysis concludes that the migraine disease management program has a high ROI informing other employers that the systematic inclusion of migraine management into corporate health management programs can be of significant benefit to the impacted individuals as well as the companies.
A115for any avoided severe complication. In the univariate sensitivity analysis the ICER result was especially sensible to CA total cost and in a lesser extension to MICS total costs. The probabilistic sensitivity analysis shows the robustness of the results. The 37.8% of the results were cost saving respect to CA. The Willingness To Pay (WTP) acceptability curves show that MICS compared to CA, had a higher probability to be accepted for the all the WTP values above US$16.000. ConClusions: MICS shows a better cost-effectiveness ratio than CA, with an ICER of US$8.326. The univariate sensitivity analysis shows the ICER result was especially sensible to CA total costs. The probabilistic analysis shows that in 36.8% of Monte Carlo simulations, MICS was cost saving respect to CA.
and the total number of prescriptions increased from 9.4 million in 1991 to 36.1 million in 2018, an increase of 285.4%. The 1 st generation AEDs prescription number declined from 2004, whereas the 2 nd generation AEDs prescriptions rose from 8.9 million in 2004 to 26.7 million in 2018, which was 74.0% of the total AEDs prescription in 2018. The 3 rd generation AEDs accounted for only 2.6% of the total prescription for AEDs in 2018 but 44.
These cost estimates highlight the need to reduce sub-optimal diet via nutritional policies for the primary prevention of cancer. The results may serve as input for economic evaluation of diet-related prevention interventions for cancer burden in the U.S. Policy makers, public health practitioners, and clinicians may use this information to formulate evidence-based strategies for primary prevention of cancer through dietary interventions.
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