Lipoic acid (LA) and eicosapentaenoic acid (EPA) have been shown to ameliorate the changes associated with hyperoxaluria. This prompted us to study the effect of EPA-LA, a new derivative, in experimental urolithiatic condition. Foreign body implantation method followed by supple-mentation of ammonium oxalate was adopted to induce stone formation in the bladder. Significant depletion in the antioxidant status was observed in the kidney and bladder of stone-forming animals, associated with increased lipid peroxidation. The present observations provide supporting evidence to the hypothesis that free radicals might be involved in causing toxicity in hyperoxaluric condition. The three drugs, namely LA, EPA and EPA-LA had reversed the above changes, but the effect was more pronounced in EPA-LA-treated stone formers. These features highlight the beneficial effect of EPA-LA wherein the potency of two drugs has been combined. The practical outcome of these findings is that the cellular antioxidant defence can be increased by the supplementation of lipoate and its derivative EPA-LA. Human & Experimental Toxicology (2002) 21, 153–158.
The healing potential of ethanolic extract of aerial parts of Sphaeranthus amaranthoides, Linn. (Asteraceae) (SAE) for treatment of dermal wounds in wistar rats was studied on excision wound models. Various parameters studied are epithelization and wound contraction. The extract was applied in thedorsal thoracic region of six excised wounded models once in a day for 16 days. The results obtained indicate that Sphaeranthus amaranthoides accelerates the wound healing process by decreasing the surface area of wound. Framycetin sulphate was used as positive control complete epithelization was observed within 16 days with Sphaeranthus amaranthoides The extract significantly enhanced the rate of wound contraction and the period of epithelialization comparable to framycetin sulfate.
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