Available data support the view that inulin. clearance (GIN) is a valid measurement of the glomerular filtration rate (GFR) in children. However, the measurement of CIN in children presents certain technical difficulties, as a constant infusion of inulin is required to obtain accurate measurements of GFR. The endogenous creatinine, which is present in plasma a t stable concentrations, would be the ideal substance in this respect, if this substance were excreted in man only by filtration at the glomeruli.The literature contains many reports on comparisons of inulin and endogenous creatinine clearances. I n most of these studies, the analytical methods used for the estimation of creatinine measure not only true endogenous creatinine, but also ('creatinine chromogens". Therefore the results obtained can not be accepted as representative for the clearance of the "true endogenous creatine" (CcR).The aim of the present paper is to report a comparison of the clearances of inulin and true endogenous creatinine in children.
Material and MethodsThe material of the present study consists of 39 children, 17 males and 22 females, ranging in age from 6 to 15 years.Cases 1-20 were patients treated for different disorders ( Table 1 ) in which involvement of kidney function was improbable. Group I (Cases 1-6) was taken as the control group. Group I1 (Cases 7-12)' consists of 6 patients in whom acidosis was induced by ammonium chloride, given in a dosage of 0.25 g/kg/day for 3-5 days before the clearance studies. Metabolic acidosis was induced in the eight patients (Cases 13-20)' of Group 111. After a fasting period of 2 days, a carbohydrate-poor, fat-rich diet was given to these patients. The clearance studies were performed on the 2-4 day after the end of the fasting period. Cases 21-35 were patients with kidney diseases. In six of these (Cases 21-27, Group IV) the clearance studies re-_. ' Cases 7-20 were used in a study of P3* excretion which will appear separately.
Summary1. The relationship between tuberculin sensitivity and tuberculosis immunity was studied in 39 cases of pulmonary sarcoidosis. The tuberculosis immunity was assessed by following the absorption of intradermslly injected BCG vaccine.3. A depression of tuberculin sensitivity was noted chiefly in cases of generalized and/or chronic sarcoidosis.3. Signs of enhanced tuberculosis immunity (the so‐called positive anergy were not to be observed in the present series. In several grave cases of sarcoidosis, absorption of radioactive BCG vaccine was instead decidedly rapid, which suggests a decrease in tuberculosis immunity.4. No parallelism emerged between the degree of tuberculin sensitivity and of tuberculosis immunity.
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