From the extracts of enzyme-or acid hydrolysed pregnancy urine and urine of newborn infants a new oestrogen metabolite has been isolated.On the basis of the physical and chemical characteristics of this compound it is concluded that it is identical with 15\g=a\-hydroxy-oestriol(oestra\x=req-\ 1 , 3 , 5 ( 1 0 ) -t r i e n e -3 , 1 5 \ g = a \ , 1 6 \ g = a \ , 1 7 \ g = b \ -t e t r o l ) .It has been reported from this laboratory that one of the quantitatively most important metabolites of radioactive 17/5-oestradiol injected to malformed infants is an oestrogenic tetrol. It has been suggested that this compound is identical with 15a-hydroxy-oestriol, or possibly with 18-hydroxy-oestriol (Hagcn et al. 1965). Continued studies revealed that this compound is a normal constituent of pregnancy urine, of the urine of newborn infants and meconium 1 Ford Foundation Fellow in Reproductive Endocrinology. Present address:
Urate is reabsorbed throughout the accessible proximal tubule and, in nondiuretic animals, between the proximal and distal tubules. Proximal absorption of urate is diminished by volume expansion but not osmotic diuresis. The high performance liquid chromatographic method is satisfactory for estimation of urate in tubular samples.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.