No abstract

Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11 C, 13 N, 15 O and 18 F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11 C and 18 F using a petawatt laser beam. The work describing the laser production of 18 F through a (p,n) 18 O reaction, and the subsequent synthesis of 2-[ 18 F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

An experimental investigation of lateral electron transport in thin metallic foil targets irradiated by ultraintense (>or=10(19) W/cm2) laser pulses is reported. Two-dimensional spatially resolved ion emission measurements are used to quantify electric-field generation resulting from electron transport. The measurement of large electric fields ( approximately 0.1 TV/m) millimeters from the laser focus reveals that lateral energy transport continues long after the laser pulse has decayed. Numerical simulations confirm a very strong enhancement of electron density and electric field at the edges of the target.

Proton and heavy ion acceleration in ultrahigh intensity ( approximately 2 x 10(20) W cm(-2) ) laser plasma interactions has been investigated using the new petawatt arm of the VULCAN laser. Nuclear activation techniques have been applied to make the first spatially integrated measurements of both proton and heavy ion acceleration from the same laser shots with heated and unheated Fe foil targets. Fe ions with energies greater than 10 MeV per nucleon have been observed. Effects of target heating on the accelerated ion energy spectra and the laser-to-ion energy conversion efficiencies are discussed. The laser-driven production of the long-lived isotope (57 )Co (271 days) via a heavy ion induced reaction is demonstrated.