As long ago as 1914 W h i t e h o u s e showed that menstrual blood withdrawn from the uterine cavity into a glass catheter clotted normally, where as menstrual blood collected from the vagina did not clot. These observations were later confirmed by L o z n e r , T a y l o r and T a y l o r (1942) among others. The clotting in the uterine cavity is assumed to occur as a consequence of liberation of thromboplastins from the endometrium. The redissolution of the clotted blood is the result of fibrinolysis [A 1 b r e c h t s en, 1956). The fibrinolytic activity of the endometrium is known to depend on a plasminogen activator in the endometrium. R y b o (1966) has recently shown that concentration! of plasminogen activators in the endometrium increases during the secretory phase, the highest concentration occurring on tke first day of the bleeding. In cases of menorrhagia the concentration of plasminogen activators was significantly increased as compared with the values of normal menstrual endometrium. The fibrinolytic activity in the endometrium was higher on the first day of the bleeding than during the premenstrual phase. B e 11 e r and G r a f (1957) considered it possible that the plasmin of menstrual blood directly destroys the fibrinogen before any clotting occurs in the uterine cavity.The aim of this investigation was to study possible clotting and lysis of blood from the uterine cavity in metropathy and abortion.
A total of 173 surgically treated cases of carcinoma of the cervix uteri are presented. Wertheim's radical hysterectomy with lymphadenectomy was performed on 137 patients. 158 patients were also given radiotherapy. The 5 year cure rate for the series as a whole was 82.1%. The operative mortality was 0.6%.Fistulae of various types were encountered in 9.8 % .During the same period, 467 patients with carcinema of the uterine cervix were treated by radiotherapy. The 5 year cure rate was distinctly better for the surgicallytreated patients with Stage I carcinoma and slightly better for those with Stage I1 carcinoma. The incidence of fistula was the same in both groups. Complications of different degrees were more numerous on the whole in th-c a s s treated by radiotherapy alone.
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