on the first model cycle in 11 studies (52%) whereas a rate per cycle was used in 4 studies (19%). Information was not clearly reported in 6 studies (29%). Costs were considered only for AE leading to hospitalization in nearly half of the studies (9/21). Disutilities were applied in 78% of all studies (15/21). ConClusions: Methods for modelling AE were heterogeneous. The lack of methodological rigor of many studies raises concerns about the incorporation of AE in CEA.
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