Polymeric waves associated with the electrochemical oxidation of salicylaldehyde and its derivatives exhibit Nernstian responses to pH variations in both buffered and unbuffered media.
Two synthetic routes to the dihydropyridazinone‐cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone‐pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro‐keto‐acid 24, with subsequent displacement of the fluoro substituent by 4‐pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.
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