The study was carried out to evaluate the influence of lipid blood plasma in patients with stable angina on some rheological properties of the erythrocytes. Our study revealed that atherogenic lipids increased erythrocyte's aggregation, but level of high density lipoproteins has no affect on the aggregation. Erythrocyte deformability of red blood cells was not associated with the plasma lipid profile.
The study was carried out to evaluate deformable and aggregative erythrocyte properties in humans under normal and pathological states and in rats exposed to various stressors. A strong correlation between the erythrocyte rheological determinants, i.e. deformability index and aggregation rate, was found under pathological and stress-induced states. The physiological significance of this phenomenon is to maintain the native structure of blood flow.
В работе приводятся данные экспериментального подтверждения и физиологическое объяснение феномена Фареуса-Линдквиста в капиллярах, используя анализ профилей осмотической деформируемости красных клеток крови. Показано дозозависимое изменение деформируемости эритроцитов в стадии изотропной сферы при формировании искусственных водных пор (нистатин) и закупорке (PbCl 2) имеющихся. Сигма-эффект снижения гематокрита и вязкости в сдвиговом потоке крови через сосуды малого диаметра вызывается обменом жидких фаз между эритроцитом и плазмой Ключевые слова: сигма-эффект, вязкость, эритроциты, деформируемость, водные поры, напряжение сдвига It is proposed a physiological and experimentally confirmed explanation of Fåhraeus-Lindqvist-effect in capillaries using the profile analyses of osmotic deformability of red blood cells. It was shown the dosedependent change of the erythrocytes deformability in the stage of isotropic spheres after forming artificial water pores (nystatin) and occlusion (PbCl 2) of available pores. The Sigma-effect reducing of hematocrit and viscosity in a shear flow of blood through the vessels of a small diameter was conditioned by the interchange of liquid phase between the erythrocyte and the plasma
The annual cycle of small ground squirrels (Spermophilus pygmaeus) consists of 2 periods: wakefulness (spring−autumn) and hibernation (winter). During the active period, ground squirrels breed (spring), accumulate fat reserves (summer) and prepare for hibernation (autumn). We suppose that the rheological properties of blood and the deformability of erythrocytes can change in different seasons of the animal's wakefulness period to adequately provide tissues with oxygen. The aim of this study was to identify possible adaptive changes in erythrocyte deformability and erythrocyte indices in ground squirrels during their active period. The deformability of erythrocytes was studied by ektacytometry in an osmotic gradient. It was found that in spring, after the arousal of ground squirrels, erythrocytes have the highest deformability (El_max), hydration (O_hyper), water permeability (El_min) and osmotic stability (∆O). In summer, compared with spring, the deformability of erythrocytes decreases, and the average volume of erythrocytes (MCV) also decreases. In autumn, before hibernation, the integral deformability of erythrocytes, their hydration, as well as the range of osmotic stability of erythrocytes increases relative to the summer period. In summer and autumn, in contrast to spring, the average concentration of hemoglobin in the erythrocyte (MCHC) increases. At low shear stress (1 Pa) in summer and autumn, osmoscan becomes a pronounced polymodal form, indicating a change in the viscoelastic properties of ground squirrel erythrocyte membranes. Thus, for the first time, we discovered seasonal variability in the deformability of ground squirrel erythrocytes, which is consistent with the spring‐summer activity of animals and preparation for hibernation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.