The hydrolytic stability of compounds is a factor of crucial importance for the storage, use, and metabolic conversion of drugs. For this reason, in continuation of our previous work [1,2] on the synthesis of effective antidepressants in the series of dibenz[b,e]azepines, we have studied their behavior in aqueous acid solutions.For this purpose, we have used the method of Raman scattering providing identification of the hydrolysis products immediately in the reaction mixture.A comparison of the Raman spectra of a crystalline sample of dibenz [b,f] [1,4]oxazepine Ia (this compound is virtually insoluble in water) and its aqueous hydrochloric acid (10%) solution reveals a most pronounced difference in the region of 1600 -1700 cm-I. For example, a band at 1613 cm-I (vC=N) characteristic of the Raman spectrum of solid Ia is absent in the spectrum of the solution, but the latter spectrum displays a new band at 1658 cm-I, which is typical of the aqueous solutions of aromatic aldehydes [3].Similar results were obtained from a comparison of the spectra of other dibenz [b,e]azepines. In all cases, dissolution
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