surgery, but with the data available 70% of them had no recurrences.Only one of all patients had an adverse event (ocular irritation).Two patients received Bioferon ® , both with OSSN. One had complete response and the other partial response with no adverse effects. Conclusion and RelevanceWe can conclude that eye drops of interferón alfa-2b are safe and effective to treat malignant pathologies and the formulation with the new drug Bioferon seems to maintain safety and efficacy, but we need more patients to confirm it.