The major allergens of P. dominulus' and Vespula vulgaris' venom, namely phoshpholipases and antigen 5s, are required to discriminate the probable sensitizing species in vespid-allergic patients.

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Background The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our goal was to assess disease characteristics and icatibant treatment outcomes in patients with HAE due to C1 inhibitor deficiency (HAE type 1 or 2 (HAE-1/2)) from Spain relative to other countries participating in IOS. Methods Descriptive retrospective analyses of data are reported from 10 centers in Spain vs 51 centers in 12 other participating countries (July 2009 to January 2019). Results No meaningful differences were identified between patients in Spain (n = 119) and patients across other countries (n = 907) regarding median age at symptom onset (15.0 vs 12.0 years) or diagnosis (22.3 vs 20.5 years). Overall HAE attack rates (total attacks/total years of follow-up) were 2.66 in Spain and 1.46 across other countries. Patients in Spain reported fewer severe/very severe HAE attacks before treatment (41.0% vs 45.9%; P < 0.0001) and, for icatibant-treated attacks, longer median time to treatment (2.9 vs 1.0 h), time to attack resolution (18.0 vs 5.5 h), and total attack duration (24.6 vs 8.0 h). Use of androgens for long-term prophylaxis was higher in Spain (51.2% vs 26.7%). Conclusion Patients with HAE-1/2 in Spain reported fewer severe/very severe attacks, administered icatibant later, and had longer-lasting attacks than did patients across other countries in IOS. These differences may indicate varying disease management practices (e.g., delayed icatibant treatment) and reporting. Efforts to raise awareness on the benefits of early on-demand treatment may be warranted. Trial registration: NCT01034969.

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Hymenoptera venom immunotherapy (VIT) is a treatment which has been shown to be effective in the protection of individuals with systemic allergic reactions caused by Hymenoptera stings. The need for a tool which shows the degree of protection afforded by VIT and the lack of useful biomarkers, has converted the Sting Challenge Test (SCT) into the gold standard for this disorder although its use has both lights and shadows. SCT with Hymenoptera is a test consisting of causing a real sting in a patient diagnosed with an allergy to the venom of the stinging insect and who normally is undergoing treatment with specific immunotherapy. In Spain, SCT is included in the list of services offered by some hospitals and forms part of their habitual clinical practice. This review aims to analyze the strengths and weaknesses of this test and describe the standardized procedure and necessary resources, based on the experience of a group of Spanish experts and a review of the literature.

Há diversos estereótipos cercando os profissionais da tecnologia e da computação, com isso, nós que fazemos parte do projeto desenvolvido pelo Programa Despertando Vocações na Tecnologia - Natal (PDVT-Natal), que pertence ao Instituto Internacional Despertando Vocações (IIDV), criamos o Papo tem parêa não, que é um programa que tem como principal objetivo humanizar o profissional, mostrando a pessoa por trás da profissão, seus hobbies, aprendizados e o caminho percorrido ao longo da sua trajetória na área tecnológica. Os programas são exibidos por meio de lives na plataforma virtual YouTube, com auxílio da plataforma Stream Yard, possuindo a duração de em média uma hora e trinta minutos. O processo de criação do programa deu-se com base no entendimento do grupo por completo, para buscar envolver o máximo de pessoas que buscam o interesse na área tecnológica. O nome dado ao programa, remete à uma expressão regional usada no interior nordestino “tem parêa não”, que tem seu significado baseado em que não existe algo igual a aquilo que foi referenciado no contexto em que o termo seja encontrado. Segundo AFONSO (2009, p. 19), as inovações tecnológicas revolucionaram as formas de comunicação social, de entretenimento e de lazer ao redor do mundo. Nas últimas décadas surgiram novas formas de comunicação social, lazer e entretenimento onde a participação de pessoas do mundo inteiro dá origem a uma nova geração, a geração C. C de conhecimento, colaboração e conectividade. Através de um computador ligado à rede, as tecnologias da informação deixam ao alcance de todos um mundo ilimitado, recheado de ambientes (reais ou virtuais) extremamente rico em informações. (AFONSO, 2009, p. 19). De acordo com esse pensamento, a criação do projeto visa interligar pessoas de diversos lugares e idades que tenham interesse e curiosidade na área tecnológica, destruindo barreiras geográficas e temporais, já que o programa permanece salvo no canal do YouTube do PDVT-Natal, além de humanizar os profissionais da área com da quebra dos estereótipos a eles condicionados.

Obtaining new and improved varieties of rice requires long and complex plant breeding programs. The early detection of desirable characteristics is a complex process, especially when seeking to improve yield, as the interaction between the environment and plants may hinder selection in early generations considerably. Techniques that facilitate the selection of plants with desirable characteristics in early generations are highly valuable to plant breeders. An indirect selection method in early generations of rice was examined by principal component analysis of performance supported by field tests with a honeycomb design. This study used double haploid lines of rice obtained by crossing two rice varieties, namely ‘Benisants’ and ‘Gigante Vercelli’. This method was compared to indirect selection using genomic tools such as high-throughput molecular marker analysis. The main factors that can be used in indirect selection have been selected by principal component analysis. The model resulting from the phenological evaluation and principal component analysis with six selected variables explained 98.73% of the total variability of yield. The variable that contributes the most to the model is the Harvest Index. The best selected lines provided 32% and 43% higher yield values than the parentals and match the results from indirect selection with molecular markers.