The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morphology showed abnormal cortical remodeling characterized by the failure to form a cylinder of compact bone with a regular marrow canal. Atypical, flattened, and large resorption lacunae with a wide resorption front on one side and systems of parallel lamellae on the opposite side were observed, resembling those formerly reported as drifting osteons. SEM morphometry documented a higher percentage of nonossified vascular/resorption area (44.3 %) in OI than in controls (13.6 %), a lower density of secondary osteons, and lower values for the parameters expressing the individual osteon size. The mean osteon total area, the mean central canal area, and the mean osteon bone area of two selected, randomized populations of secondary osteons were significantly higher (p < 0.001, p = 0.028, and p < 0.001, respectively) in control bones than in OI. The mean ossified matrix area was not significantly different, but the mean secondary osteon number and mean density were higher in controls (both p < 0.001). Osteon wedges were carried out to correct the native deformity of OI III and morphologic analysis suggested that the abnormal remodeling pattern (with "drifting osteons") may result from the altered load and tensile stresses on the deformed tubular bones.
New data are presented on the taxonomy and distribution of some species of Otiorhynchus Germar, subgenus Arammichnus Gozis, in Sicily. Otiorhynchus (Arammichnus) ferrarii Miller is recorded from Sicily for the first time. Three new species are described: Otiorhynchus (Arammichnus) vagans n. sp., Otiorhynchus (Arammichnus) pseudosetosulus n. sp., and Otiorhynchus (Arammichnus) adrianus n. sp. The number of known Otiorhynchus (Arammichnus) species thereby rises to 66; 25 of which are present in Sicily and the lesser Sicilian islands.
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