There was a high (14.5%) prevalence of cobalamin deficiency as demonstrated by elevations in serum methylmalonic acid and homocysteine in addition to low or low normal serum cobalamin levels in elderly outpatients. The serum cobalamin level was insensitive for screening since similar numbers of patients with low normal serum cobalamin levels of 201-300 pg/mL compared with patients with low cobalamin levels (< or = 200 pg/mL) had markedly elevated metabolites which fell with cobalamin treatment. Additional studies will be required to define the full clinical benefit from treatment with Cbl in elderly subjects.
Long-Evans black-hooded rats treated via stomach tube with 160,000 USP units of retinyl acetate (vitamin A) in 0.5 ml Mazola corn oil on gestational days 15--19 deliver normal-sized litters with significantly decreased viability. Vitamin A is known to effect the differentiation and to stimulate the growth of epithelial cells. Additionally, lung epithelia undergo marked morphologic and physiologic changes late in gestation. Thus the effects of hypervitaminosis A on developing lung constitute an excellent system for the study of teratogenesis late in gestation. Non-hilar, right lower-lobe sections of lungs from the vehicle control and experimental groups, compared via quantitative light microscopy, revealed no significant difference in gross overall histologic appearance on any given day, either in the total number of airways present in the volume of lung sectioned or in the percent area of any individual airway occupied by cells or by lumen. The only significant difference was in the number of cells per square micrometer in that region of an airway occupied by cells. Additionally, there was a significant difference between the control and experimental mitotic indices on gestational days 18 and 19. Thus in the experimental group the number of cells lining the developing airways increases, while the absolute thickness of this cellular layer remains constant. Transmission electron microscopy (TEM) fails to reveal any morphologic differences between control and treated type II pneumatocytes. The increased number of respiratory cells in what otherwise appears to be normal lung may create a diffusion-perfusion imbalance or other difficulties contributing to the heightened neonatal mortality resulting from teratogen exposure late in gestation.
sensitive radioautographic technique and radial immunodiffusion with monospecific antisera. Thirteen of these proteins (albumin, IgG, IgA, IgM, complement C,, haemopexin, haptoglobin, transferrin, 6,antitrypsin, ceruloplasmin and 9.5 S glycoprotein) were found to bind zinc. We then measured the serum concentrations of these proteins in five patients on each of 6 days. Three of the patients underwent inguinal hernia repair and two had suffered a myocardial infarction. The total serum zinc fell over the first 3 days and then rose towards normal concentrations. Of the serum proteins that bound zinc three, including albumin, fell over the first 3 days and subsequently altered little; four, including o+nacroglobulin, altered little in concentration over the 6 days whilst five proteins rose significantly after the second day (acute-phase proteins).These results demonstrate the lack of correlation between serum zinc and albumin concentrations and suggest that the fall and subsequent rise in serum zinc could be attributed to the increase in concentration of the acute-phase proteins. With this information it might be possible to calculate a free zinc index, which would be more valuable clinically than total serum zinc estimations. BILIRUBIN AND BILE ACID EXCRETION AFTER PERCUTANEOUS BILIARY DRAINAGE IN PATIENTS WITH CHOLESTASIS
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.