BACKGROUND Solitary thyroid nodule in contrary to multiple lesions is uncommon. If sonologically detectable, irrespective of sex, age group above 45 years and in non-endemic areas the malignancy rates are high. CEUS is widely done in other Asian countries, seldom used in India. As cost-effective contrast study unlike CT and MRI contrast with least adverse reactions will really be a value added tool in future and adjunct to routine real-time 2D ultrasonography. The objective of the study is to study the CEUS in correlation with high resolution advanced ultrasonography in diagnosis of solitary thyroid nodule. MATERIALS AND METHODS We have decided the sample size of 33 based on previous one year record in our hospital. We enrolled symptomatic patients referred to Radiology Department for ultrasonography from other different specialities, of which 18 cases were with solitary lesions and another 15 cases were with multiple lesions. Contrast agent Sonovue was available in powdered form, mixed with 40-60 mL saline for maximum contrast and given according to body weight of the participants. To find the significance in categorical data, Chi-square test was used. The p-value < 0.05 is considered as significant level. RESULTS There were 17 females and 16 males with overall mean (+SD) age being 43.55 (+5) years. Mean age for female and male was 43.5 years and 54.3 years respectively. Mean (+SD) size of nodule was 2.5 (+1.5) cm and commonly seen on the right side as compared to the left side. CONCLUSION CEUS prove to be definitely adjunct to routine real-time ultrasonography in challenging and problem solving solitary thyroid nodule. Future prospects are yet to be defined for CEUS to include as value added tool along with USG in routine ultrasonography screening.
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