To maximize the islet isolation yield for successful islet transplantation, the key task has been to identify an ideal pancreas donor. Since implementation of the islet donor score in donor selection, we have consistently obtained higher islet yields and transplantation rates. In this study, we tested whether assessing donor height as an independent variable in combination with the donor score could improve the pancreas donor selection. Donor and islet isolation information (n = 22) were collected and studied between 2011 and 2012. Pearson correlation analysis was used in statistical analysis. Donor height as an independent variable was significantly correlated to the weight of the pancreas, pre-Islet Equivalents (pre-IEQ), post-IEQ, and IDS (P <.05). When donor with height of 179 cm ± 3 was selected in combination with IDS > 80, the clinical islet transplantation rate reached 80%.
The present study was aimed to investigate the age-related changes of the serum IGF-I, leptin, insulin, triiodothyronine (T 3 ) and thyroxine (T 4 ) levels in pigs of different breeds. Jinhua and Landrace gilts were sampled at 35, 80 and 125 days of age, respectively. Serum hormone levels were measured with RIA. Serum IGF-I, leptin levels increased with age and displayed breed differences. Jinhua gilts showed lower (P<0.05) serum IGF-I and higher (P<0.05) leptin levels compared with Landrace gilts. In contrast, serum T 3 , T 4 levels decreased with age, Jinhua gilts had lower serum T 4 levels at 80 days of age. Meanwhile, Jinhua gilts had higher (P<0.01) serum insulin levels. Serum leptin, IGF-I, insulin and T 4 levels correlated with carcass fat content (P<0.05), which suggested that the breed differences of serum hormone levels may contribute to the different phenotypes in adipose tissue deposition.
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