Theoretical conformational analysis was used to study the spatial structure and conformational properties of myelopeptides, bone-marrow peptide mediators. The low-energy conformations of three hexapeptides MP-1 (Phe-Leu-Gly-Phe-Pro-Thr), MP-2 (Leu-Val-Val-Tyr-Pro-Trp), and MP-3 (Leu-Val-Cys-Tyr-ProGln) were found, the values of dihedral angles of the backbone and side chains of the amino acid residues constituting these peptides were determined, and the energies of intra-and interresidual interactions were estimated.
Opioid peptides are currently considered the most studied group of peptide signaling substances. Opium causes pain relief, sedation and falling asleep, as well as a euphoric state and a number of vegetative reactions. Opioid peptides are of animal and plant origin. A number of exogenous peptides obtained from food have opioid-like properties. Such peptides were called exorphins, there are dozens of representatives. The alpha-laktorphine molecule is a representative of this class. The conformational possibilities of the Tyr-Gly-Leu-Phe alpha-lactorphine molecule were studied by the method of theoretical conformational analysis. The potential function of the system is chosen as the sum of non-valence, electrostatic and torsion interactions and the energy of hydrogen bonds. The low-energy conformations of the alpha-laktorphine molecule, the values of the dihedral angles of the main and side chains of the amino acid residues that make up the molecule were found, and the energy of intra- and interresidual interactions was estimated. It was shown that the spatial structure of the alpha-laktorphine molecule can be represented by eleven forms of the main chain. The results obtained can be used to elucidate the structural and structural-functional organization of exorphin molecules.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.