2039 to EUR 9346, depending on care required, more costly than SREs without hospitalization (n= 165). These SREs had median costs of EUR 200 to EUR 1912, depending on care required. ConClusions: The impact of SREs on total costs could justify policy aimed at actively preventing SREs, e.g. with radionuclide therapy, possibly resulting in better quality of life and cost-reduction. Treatment of prostate cancer with bone metastases is not very costly compared to lung-and breast cancer with similar metastases. However, novel therapeutic options may dramatically increase treatment costs in the near future and proper head-to-head cost-effectiveness studies of all treatment modalities are therefore necessary.
PCN72objeCtives: To assess the intramural resource use and associated costs of treating patients with prostate cancer, metastatic to the bone, focusing on Skeletal Related Events (SREs). Secondary, to quantify the impact of SREs and different treatment strategies on total costs. Methods: A retrospective bottom-up cost of illness study performed at a large regional teaching hospital in the Netherlands. Results: A total of 136 patients were included, follow-up started at diagnosis of bone metastases and stopped at death. The mean total costs were EUR 17.931 per patient (median EUR 14.039), inpatient days were the most costly category at a mean of EUR 5955 (median EUR 3995). SREs that required hospitalization (n= 53) were, at median costs of EUR
The combined incremental budget impact across both public health care institutions is 5.2%. ConClusions: Crizotinib, the only drug approved for the treatment of ALK+ advanced NSCLC patients has a minimal incremental budget impact on the overall expenditure within the two main Mexican public health care institutions.
A109(AF). Methods: We collected a sequential, prospective, convenience sample of patients 50 years of age or older, admitted between December 2010 and March 2013 diagnosed with ischemic stroke, excluding lacunar infarct, transitory cerebral ischemia, recurrent stroke or modified Rankin index greater than 2 prior to this episode. The presence of AF was sought with electrocardiogram and in some cases was studied with Holter. For a separate analysis, we matched for age and admission NIHSS score, in a 1:1 ratio, patients with and without AF. Variables measured in all cases were: age, gender, admission and discharge NIHSS, modified Rankin index, and CHA2DS2VASC score. Prospectively, we collected in-hospital resource use and costs incurred during the acute event. Exchange rate 1805 Colombian pesos = 1 American dollar (USD). Results: 166 patients were analyzed, 125 without and 41 with nonvalvular AF. For the paired analysis, we considered 37 patients with and 37 without AF. The average total cost of acute care for all stroke patients was USD$4,163
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