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sB7-H4 is involved in the regulation of immune tolerance in women with PE in the third trimester. In the first trimester of pregnancy, sB7-H4 might serve as a predictive immunological biomarker for women who are at elevated risk of developing PE.

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Ob,erlJation.-I must finally remark that some of the most rapidly fatal cases in this epidemic were unattended by spasms or cramps, and but little vomiting or purging. The patients were struck down at once. Of course the plan of treatment that I have proposed can be of little or no avail in such cases.