Laser Doppler flowmetry was applied to human teeth to study whether blood How in the pulp can be recorded. In sensitive, intact incisors the level of the output signal Ironi the flowmeter was clearly distinguishable from that obtained in adjacent nonsensitive or pulpeetomized teeth. Heart beat synchronous oscillations, which were present in the recording signal from normal teeth, were absent in nonvital teeth. Local injection of lidocaine (20 mg/ml) with adrenaline (12.5 μg/ml) caused a pronounced and long‐lasting reduction of the flowmetric values in healthy teeth. The oscillations were also reduced in amplitude. Repeated recordings showed good reproducibility. Thus, changes in blood (low may be assessed in a tooth by tin's non‐invasive method. The instrument is a promising tool in the clinical evaluation of pulp vitality following traumatic injuries.
Topical treatment with oxytocin appears to improve vaginal atrophy in postmenopausal women. A limitation of this pilot study is that it was based on a small study population hence the results should be regarded with caution. Larger studies are in progress to establish the possibility of using oxytocin as a clinical treatment for vaginal atrophy.
Effects of 2% lidocaine with epinephrine (1:100,000) administered by the various local anesthetic techniques--i.e., infiltration, mandibular block, and intraseptal injection--on pulpal blood flow in dogs were determined using the 15 microns radioisotope-labeled microsphere injection method. The pulpal blood flow decreased significantly with all three techniques; however, the most drastic reduction occurred in the molar teeth with the intraseptal injection. When 2% lidocaine without epinephrine was used in the intraseptal injection, pulpal blood flow increased significantly.
The aim of the study was to investigate in commonly used experimental animals the pulpal wall and the dentin with special reference to the number and diameter of the dentinal tubules. The coronal dentin of a total of 26 permanent, intact teeth from rat, cat, dog and monkey was fractured experimentally. The calculations were based on the study of about 150 scanning electron microscope (SEM) photographs of fractured surfaces and of the pulp chamber wall. The number of dentinal tubules per unit area was calculated and the tubule diameter was measured at various distances from the pulp. The tubules were found to be widest at the pulpal wall, where the mean diameter ranged form 1.7 to 2.8 mum, the highest value being found in monkey and the lowest in the incisors of rat. In the middle part of the dentin the mean diameter varied from 1.0 to 1.3 mum and at the periphery it was 0.6 to 0.9 mum. The largest number of tubules per unit area was found immediately incisal of the pulp horn and the smallest number cervically, near the enamel. At the pulpal wall the mean number of the tubules ranged from 50,000 to 90,000/mm2, in the middle of the dentin it was between 37,000 and 50,000/mm2 and at the periphery it was between 10,000 and 25,000/mm2. In all species examined the dentinal tubules showed a straight course, except in incisors of rat, where local irregularities were seen. A comparison was also made between the species studied and homo with respect to the number and width of the dentinal tubules.
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