Haemolytic episode in G6 PD deficient workers exposed to TNT. This is a report on three cases of acute haemolytic disease in glucose-6-phosphate dehydrogenase (G6 PD) deficient workers exposed to trinitroluene (TNT). The courses of the haemolytic crises have several features in common, the most striking being the onset of the disease within two to four days after the start of exposure, and the fact that this has been the first and so far the only haemolytic episode in their lives in spite of detailed medical records of past diseases, injuries, and medications during 12 to 16 years preceding the haemolytic crisis and five to nine years following the disease.The lowest haemoglobin levels for the three patients were 4 0, 6-8, and 8-2 g/dl respectively; haematocrit values were 17 and 24 %; reticulocytes rose in case 1 to 26-2 %, in case 2 to 26%, and in case 3 to 10%.Indirect bilirubinaemia was increased in two patients (5-1 and 2-6 mg/100 ml) and stercobilinogen was as high as 2150 mg/24 hr in one patient. The presence of the metabolite monoamino 2-6 dinitrotoluene was proved in the urine of case 3 and reached 21 y %.The possibility of a dose-response relationship is briefly discussed and the risk of exposing G6 PD individuals in chemical processes is mentioned.The exposure of many thousands of workers to TNT, the most commonly used explosive since the first world war, has resulted in the extensive study of its toxicity (von
Several immunologic parameters, both humoral and cellular, were studied in the serum and peripheral blood lymphocytes derived from chest x-ray-negative, asymptomatic asbestos workers. All humoral and cellular parameters were intact, except the con-A-induced T cell suppressor activity and T cell division in autologous mixed lymphocyte reaction, which were significantly elevated in the asbestos plant workers. The significance of these increased T cell activities in asbestos exposed people is not clear, and further clinical and immunological follow-up is warranted.
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