Background: Non-motor symptoms (NMS) in Parkinson's disease (PD) differ from those in essential tremor (ET), even before a definitive diagnosis is made. It is not clear whether patient's knowledge of the diagnosis and treatment influence their subsequent reporting of NMS.Methods: 1 year after a clinical and instrumental diagnosis, we compared the motor impairment (Movement Disorders Society (MDS)-Unified Parkinson's Disease Rating Scale-III) and non-motor symptoms (NMSQuest) in PD (n531) and ET (n521) patients.Results: PD patients reported more NMS than did the ET patients (p50.002). When compared to their baseline report, at follow-up, PD patients reported less nocturia (p50.02), sadness (p50.01), insomnia (p50.02), and restless legs (p50.04) and more nausea (p50.024), unexplained pain (p50.03), weight change (p50.009), and daytime sleepiness (p50.03). When compared to their baseline report, ET patients reported less loss of interest (p50.03), anxiety (p50.006), and insomnia (p50.02). Differences in reported weight change (p,0.0001) and anxiety (p50.001) between PD and ET patients were related to pharmacological side effects or to a reduction in the ET individuals.Discussion: The reporting of NMS is influenced by subjective factors, and might vary with the patient's knowledge of the diagnosis or the effectiveness of treatment.
Ein akutes Aneurysma dissecans der Aorta tritt nur selten bei jungen Patienten auf. Hume und Porter fanden unter 68 Fällen von dissezierendem Aortenaneurysma 4% in einem Alter unter 20 Jahren. Bei 505 Fällen, über die Hirst u. Mitarb. berichteten, betrug die Häufigkeit unter 20 Jahren ungefähr 2°/o. Unter 172 an Aneurysma dissecans verstorbenen Patienten beobachteten Adelson u. Mitarb. nur 2 Jungen unter 20 Jahren.
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