IV in three gerbils. 123I-FP CIT was used in five gerbils to investigate dopamine transporters (DAT). 99mTc-ECD perfusion scan was performed in four gerbils for anatomical identification. Results. Image quality of the 5-HT2A receptor radioligand studies improved substantially after P-gp inhibition with cyclosporine. Specific binding to the 5-HT2A receptors and DAT sites was observed by the regional distribution of the radioactivity in the brain which correlated well with the known presence of 5-HT2A receptors and DAT sites (cortical areas and basal ganglia) versus low uptake in the cerebellum. Using the HiSPECT system, tomographic images of 1.4 mm resolution can be obtained. Conclusion. These results indicate that the use of HiSPECT in Mongolian gerbils is feasible and that the aforementioned biological markers can be used to investigate the biological base of stereotypies in gerbils.
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