Factor VII (FVII) deficiency is the most common autosomal recessive inherited bleeding disorder, with an estimated incidence of one per 500 000 cases in the general population. 1 Bleeding manifestations from FVII deficiency are heterogeneous in regard to severity and affected sites and, in many cases, correlate poorly with circulating FVII levels. Based on data from large registry studies, the International Society on Thrombosis and Haemostasis (ISTH) classifies FVII deficiency as: severe, FVII <10% (greatest risk for major spontaneous bleeding); moderate, 10%-20% (at risk for mild spontaneous or triggered bleeding); and mild, 20%-50% (usually
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