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Despite the extensive use of nanoparticles (NPs) in various fields, adequate knowledge of human health risk and potential toxicity is still lacking. The human lymphocytes play a major role in the immune system, and it can alter the antioxidant level when exposed to NPs. Identification of the hazardous NPs was done using in vitro toxicity tests and this study mainly focuses on the comparative in vitro cytotoxicity and genotoxicity of four different NPs including cobalt (II, III) oxide (Co3O4), iron (III) oxide (Fe2O3), silicon dioxide (SiO2), and aluminum oxide (Al2O3) on human lymphocytes. The Co3O4 NPs showed decrease in cellular viability and increase in cell membrane damage followed by Fe2O3, SiO2, and Al2O3 NPs in a dose-dependent manner after 24 h of exposure to human lymphocytes. The oxidative stress was evidenced in human lymphocytes by the induction of reactive oxygen species, lipid peroxidation, and depletion of catalase, reduced glutathione, and superoxide dismutase. The Al2O3 NPs showed the least DNA damage when compared with all the other NPs. Chromosomal aberration was observed at 100 µg/ml when exposed to Co3O4 NPs and Fe2O3 NPs. The alteration in the level of antioxidant caused DNA damage and chromosomal aberration in human lymphocytes.

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Demand for fuel and the use of petroleum products are increasing day by day which causes serious problems such as petroleum depletion, environment degradation etc. So biodiesel is a good alternative for conventional diesel fuel. By using biodiesel there are also some disadvantages such as high oxides of nitrogen, high fuel consumption and higher density. To overcome this problems from biodiesel using additives. Additives play an significant role in enhancing the properties of biodiesel. In this context, oxygenated additives such as Alimina which are rich in oxygen content are used. Biodiesel is obtained from honge oil by transesterification process and waste plastic oil is obtained by pyrolisis process. The experiment work is done by a CI engine using honge biodiesel, waste plastic oil and alumina nanparticles as an additive. The present investigation was to study the combustion and performance characteristics of all the blends by compare them with diesel. Experimental results show that performance and combustion characteristics improved with B20 biodiesel blend with WPO(waste plastic oil) and with or without nanoparticles as additive. The thermal efficiency will increase and SFC( Specific fuel consumption) is better in case of oxygenated additive blend. Considerable reductions parameters like carbon monoxide, unburned hydrocarbon and increases in nitrogen oxide emissions are attained while using B20 biodiesel blend and B20 biodiesel blend with waste plastic oil compared with diesel. However there is a significant reduction in CO, UBHC and NOx emission parameters for B20 biodiesel blend with WPO and nanoparticles as an additive.