PurposeTypically in Korea, for a standard dose (0.4 mg) of tamsulosin, two low doses (0.2 mg) are administered. The aim of this study was to evaluate and compare the efficacy of tamsulosin (0.2 mg and 0.4 mg) and alfuzosin (10 mg) in the treatment of lower ureteral stones.Materials and MethodsA total of 141 patients presenting with a single 4- to 10-mm sized lower ureteral stone were randomly assigned to 4 groups. Patients in group 1 (n=41) and group 2 (n=30) received an oral dose of 0.2 mg tamsulosin once and twice daily, respectively, and patients in group 3 (n=36) received a daily oral dose of 10 mg alfuzosin. Patients in group 4 (n=34) received trospium chloride only. The spontaneous passage of stones, the stone expulsion time, and adverse effects were evaluated.ResultsThere were no significant differences in patient background, including age, sex, BMI, stone size, stone side, and symptom duration. The spontaneous stone passage rate through the ureter was higher and the stone expulsion time was faster in groups 1, 2, and 3 than in group 4. There were no statistically different changes in groups 1, 2, and 3. The adverse effects observed in all groups were comparable and were mild.ConclusionsTamsulosin at 0.2 mg and 0.4 mg and alfuzosin (10 mg) proved to be safe and effective. A first cycle of medical expulsive therapy with tamsulosin 0.2 mg could be considered as an option in the management of single lower ureteral stone.
The synthesis of the zinc phosphido clusters [Zn 2 -(μ-PPh 2 ) 2 (PPh 2 ) 2 (NC 5 H 5 ) 2 ] (1) and [Zn 4 (μ-PPh 2 ) 4 (OAc) 4 (NC 5 H 5 ) 2 ] (2) is presented. The clusters are accessed via the reaction of Zn(OAc) 2 with differing amounts of Me 3 SiPPh 2 . When 1 was heated under solvothermal conditions in pyridine, it yielded micrometer sized metallic zinc crystals via the reduction of Zn II by the diphenylphosphido ligands, forming tetraphenyldiphos- [a]
The Cover Feature shows the molecular structure of zinc‐phosphido clusters with a background of a sun‐filled beach on the southern coast of Sardinia, Italy. These clusters can be used to prepare zinc phosphides, promising materials for photovoltaic applications. The 8‐membered ring in the Zn4P4 cluster adopts a boat‐boat conformation in the solid state. The life‐saving boat depicted also symbolizes the contribution that photovoltaic materials can play in addressing climate change. More information can be found in the Full Paper by K. Lee, Y. Huang, and J. F. Corrigan.
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