commenced with reductive amination of methyl 4-aminobenzoate (8) with 4-nitrobenzaldehyde to form the secondary amine 9. The substituted benzoic acid 10a was converted to the corresponding acid chlorides using oxalyl chloride and treated Table 2. Inhibitory Activities of 15d, 19a−t, and 21a,b against PDHK1/2/3/4 a Radiometric biochemical kinase assay. b ND stands for not determined. * Average value of two independent assays.
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