A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.

Highly sensitive biosensing of concanavalin A (Con A) has been developed based on the attenuation of FRET efficiency between amine-terminated quantum dots and mannose-stabilized Au nanoparticles in the presence of Con A, which inhibits the H-bonding formation of the QDs-AuNPs assembly, thereby causing the fluorescence recovery.Scheme 1 Schematic illustration of (A) FRET between amine-terminated QDs and mannose-stabilized AuNPs, and (B) Con A-induced attenuation of FRET.

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