BackgroundThe major disadvantage of rocuronium is the withdrawal movement associated with its injection. The analgesic effect of perioperative gabapentin has been evaluated. We investigated the effects of gabapentin on the withdrawal movement induced by rocuronium injection.Methods86 ASA physical status I or II patients, aged 18-69 years who were scheduled to undergo elective surgery with general anesthesia were enrolled. Patients were randomly allocated into two groups to receive either gabapentin 600 mg or placebo 2 hours prior to surgery. The patient's response to rocuronium injection was graded using a 4-point scale.ResultsThe incidence of withdrawal movement after rocuronium administration was significantly lower in the gabapentin group (55.0% in the control group vs 28.6% in the gabapentin group). The number of patients with generalized response indicating severe pain, was 9 (22.5%) in the control group and 3 (7.1%) in the gabapentin group.ConclusionsPretreatment with a single oral dose of gabapentin 600 mg reduced the incidence and severity of withdrawal movement after rocuronium administration.
removed, disconnected from the old (thrombosed or otherwise damaged) pump, and connected to the new pump. Thereafter, the polytetrafluoroethylene (Gore-Tex) graft should be closed (using suture or clips) to protect against adhesion and to facilitate any unlikely future exchange of the pump. We use the technique described for all HeartWare HVAD implantation approaches, that is, median sternotomy and left lateral or bilateral thoracotomy. To avoid twisting of the outflow graft during aortal anastomosis, the position of the black line on the outflow graft should be kept in mind. This technique has been routinely used in our center since the last 100 HVAD implantations. No evidence of increased infection has been noted. In 2 cases in which the kinking protector was covered, pump exchange was performed fast and without any complications. During heart transplantation in the described patients, reopening of the chest and separation of the heart from pericardium also were less traumatic.
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