Megalin has been proposed as an endocytic receptor for aminoglycosides as well as estrogen and androgen. We aimed to investigate the otoprotective effects of antiandrogens (flutamide, FM) on kanamycin (KM)-induced hearing loss in rats. Rats were divided into four groups. The KM group was administered KM (20 mg/kg/day) for 5 days, while the FM group received FM (15 mg/kg/day) for 10 days. In the KM + FM group, KM and FM (15 mg/kg/day) were simultaneously injected for 5 days and then FM was injected for 5 days. Auditory brainstem responses were measured. Western blotting and/or quantitative reverse transcriptase-polymerase chain reaction were performed for megalin, cytochrome P450 1A1 (Cyp1a1), Cyp1b1, metallothionein 1A (MT1A), MT2A, tumor necrosis factor (TNF)-α, caspase 3, and cleaved caspase 3. The FM + KM group showed attenuated auditory thresholds when compared with the KM group at 4, 8, 16, and 32 kHz (all p < 0.05). The KM + FM group showed lower megalin and Cyp1b1 levels than the KM group (all p < 0.05). The KM + FM group revealed lower MT1A, TNFα, and caspase 3 protein levels, compared with those in the KM group (all p < 0.05). Androgen receptor inhibition protects against cochlear injuries in KM-induced hearing loss rats by attenuating megalin expression, revealing anti-inflammatory and anti-apoptotic effects.
Purpose: The purpose of this study is to examine the relationship between attitude toward death among Korean hostess (room salon/bar) in Busan and their suicide-related factors.Methods: The questionnaires were administrated to 120 Korean hostess. The questionnaires consist of 7 major concepts: death as liberation, death as natural phenomenon, fear of death, avoidance of thought about death, fear for the impact of death on family, frequency of thought of death, their capacities to resist suicidal impulses.Results: Interestingly, satisfaction for hostess working in room salons with their monthly incomes was negatively correlated with frequency of thought of death and was positively related to their capacities to resist suicidal impulse. Moreover, in terms of the factors influencing 'their capacities to resist suicidal impulse', for hostess working in room salons, 'fear for the impact of death on family,' and 'satisfaction with their monthly income' were found to significantly influence 'their capacities to resist suicidal impulses'. However, for hostess working at bars, 'death as liberation' was found to be the only one factor showing significant effect on 'their capacities to resist suicidal impulses'.Conclusion: For hostess working in room salons, their perceived monetary reward seems to affect their attitudes toward death and suicide-related thoughts. Understanding a person's attitudes toward death can be another way to help people in a difficult situation to prevent them from carrying out the worst. ■ keyword :|Korean Hostess|Room Salon and Bar|Attitude toward Death|Suicidal Ideation|Capacity toResist Suicidal Impulses|
To develop a more efficient computer-based empathy program that enables medical students to increase their empathy levels, and to test its applicability to medical students. We developed PACP (the Pain Assessment Computer Program) for measurement of medical students' levels of recognition of another's pain. An empathy questionnaire was administered to 145 medical students before and after the PACP. In the high empathy group, the scores for cognitive empathy increased significantly after completion of the PACP, while affective empathy scores showed no significant change. In contrast, in the low empathy group, both cognitive and affective empathy scores increased significantly after the PACP. The PACP effectively increased cognitive empathy for the high empathy group, and increased both cognitive and affective empathy, particularly for the low empathy group. Given the fact that existing empathy education programs are time-consuming and costly, and the demand for more efficient empathy education is high, the PACP as a useful tool can be applicable to medical students, particularly those with low empathy in order to enhance their empathic abilities within a short period of time.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.