In this study, the distribution of giant N. jellyfish by the echo counting method was investigated in the East China Sea, where giant N. jellyfish are known to breed and migrate to the coastal waters of Korea mainly in summer. In addition, the distribution densities by the survey method were compared with the sighting and trawl surveys. In the case of the East China Sea area and the Gijang coastal area, a split beam type scientific echosounder (EK60, Simrad, Norway) and Acoustic data at 38 and 120 kHz were collected while moving at 6–7 kts. In the coastal waters of Korea, acoustics data at 38 and 120 kHz were collected with a split beam type scientific echosounder (EK80, Simrad, Norway) attached to the bottom of the R/V Tamgu No. 21. In the East China Sea, the average distribution densities of acoustic, sighting, and trawl surveys were 8355.7 (10−6 ind/m3), 162.2 (10−6 ind/m3), and 792.5 (10−6 ind/m3), respectively. The average densities in the coastal waters of Korea of acoustic, sighting, and trawl surveys were 2238.7 (10−6 ind/m3), 664.9 (10−6 ind/m3), and 432.9 (10−6 ind/m3), respectively. The average distribution density of the acoustic survey conducted on 21 July 2020 in the coastal waters of Gijang was 1024.5 (10−6 ind/m3), and the sighting survey showed 48.8 (10−6 ind/m3). The sighting surveys conducted on 22 July 2020 were 393.3 (10−6 ind/m3) and 19.6 (10−6 ind/m3). The average distribution density for the acoustic survey performed on 23 July 2020 was 99.0 (10−6 ind/m3), and for the sighting survey was 197.2 (10−6 ind/m3). When comparing the results of the acoustic survey with the results of the sighting and the trawl surveys, all surveys except for the survey conducted on 23 July 2020 showed that the acoustic survey was higher than other survey methods.
Erythropoietin-producing human hepatocellular carcinoma receptor B1 (EPHB1) is a member of the Eph family of receptor tyrosine kinases that mediate vascular system development. Eph receptor overexpression has been observed in various cancers and is related to the malignant transformation, metastasis, and differentiation of cancers, including hepatocellular carcinoma (HCC). Eph receptors regulate cell migration and attachment to the extracellular matrix by modulating integrin activity. EphrinB1, the ligand of EPHB1, has been shown to regulate HCC carcinogenesis. Here, we sought to determine whether EPHB1 polymorphisms are associated with hepatitis B virus (HBV)-infected liver diseases, including chronic liver disease (CLD) and HCC. We genotyped 26 EPHB1 single nucleotide polymorphisms (SNPs) in 399 Korean CLD, HCC, and LD (CLD+HCC) cases and seroconverted controls (HBV clearance, CLE) using the GoldenGate assay. Two SNPs (rs6793828 and rs11717042) and 1 haplotype that were composed of these SNPs were associated with an increased risk for CLD, HCC, and LD (CLD+HCC) compared with CLE. Haplotypes that could be associated with HBV-infected liver diseases by affecting downstream signaling were located in the Eph tyrosine kinase domain of EPHB1. Therefore, we suggest that EPHB1 SNPs, haplotypes, and diplotypes may be genetic markers for the progression of HBV-associated acute hepatitis to CLD and HCC.
Gastric cancer, the second leading cause of mortality by cancer in the world, shows particularly high incidence and mortality in Korea. To screen the causative genes or loci that control the transition from gastritis to gastric cancer, whole genome approach was applied using Illumina's 510S SNP chip technology. One of the interesting associated genes, HLA-DRA1 was investigated. HLA-DRA gene is very limited in polymorphism compared to the highly polymorphic HLA-DRB1, 3, 4, and 5 loci. HLA-DR alpha protein has roles as a non-polymorphic partner for HLA DR-beta for transport and surface expression as a functional HLA-class II protein. The expression level of the HLA-DR alpha/beta on the cell surface may be controlled by the transcriptional level of the HLA-DR alpha. To test this hypothesis, we tested susceptibility to gastric cancer compared to gastritis in terms of SNPs, haplotypes, and diplotypes covering the HLA-DRA promoter region. To find causative SNP(s), the whole linkage disequilibrium (LD) region of the significant haplotype using more than 20 Koreans were sequenced. We found that a diplotype composed of significantly associated SNPs and a haplotype was associated with susceptibility to gastric cancer significantly. These data suggested that the expression level of HLA-DRA might control the HLA-DR protein levels on the cell surface.
PLCG1 (Phospholipase C, gamma 1) as an important component of signal transduction processes involved in several cellular processes, including mitogenesis, differentiation, transformation, and tumor migration. We have examined association between polymorphisms of the PLCG1 gene and the risk of transformation from chronic liver diseases (CLD) to hepatocellular carcinoma (HCC). Total of 314 Korean subjects, 96 patients with HCC and 218 patients with CLD were included in this case‐control study. Single nucleotide polymorphisms (SNPs) of PLCG1 gene were searched for and genotyped using the GoldenGate genotyping assay. Only one SNP among the six SNPs of PLCG1 tested was significantly associated. This is a non‐synonymous SNP in exon 21 coded for SH3 domain of PLCG1. The risk of HCC was significantly lower in patients with the G/G genotypes than in those G/A and A/A genotypes. The result from our study provides a novel evidence for an association of the PLCG1 polymorphism with HCC and a genetic susceptibility marker in Korean population.
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