Fus regulates translation of APC-associated RNAs at cell protrusions and misdirects their translation in cytoplasmic granules upon overexpression or expression of ALS–linked Fus mutants.

Temporally regulated formation of RNA granules containing cyclin B1 transcript is critical for the precise timing of translational activation.

Amyotrophic lateral sclerosis–associated mutations promote the formation of cytoplasmic FUS inclusions. In this study, Yasuda et al. show in fibroblasts and neurons that kinesin-1 is sequestered in FUS inclusions, resulting in a loss of detyrosinated microtubules and mislocalization of specific RNAs.