Please list the following information on your separate title page in Word .DOC format in the order listed below and upload as a Title Page file at submission 1. Manuscript Title (50 word maximum) Components of Endocannabinoid Signaling System are Expressed in the Perinatal Mouse Cerebellum and Required for its Normal Development 2. Abbreviated Title (50 character maximum) Endocannabinoids Shape Cerebellar Development 3. List all Author Names and Affiliations in order as they would appear in the published article
The cerebellum is the only folded cortical structure present in both rodents and humans, potentially allowing mechanistic studies across species. We trained a deep convolutional neural network to predict biological sex from midline cerebellar MRI images, and identified anterior midvermis lobules and white matter as morphological determinants of sex by heatmap backpropagation. Our comparative cross species analysis shows that in mice, like in humans, the extent of anterior vermis folding and the shapes of white matter exhibit sex-dependent differences. In both species, sex and anterior vermis folding patterns influence hand/forelimb dexterity, nevertheless, neither sex nor the extent of folding are good predictors of an individual′s behavior, because the variability in performance between individuals is far greater than the differences between conditions. Finally, utilizing mice constitutively lacking CB1 cannabinoid receptors, we identify developmental cannabinoid signaling as a novel molecular mechanism limiting secondary fissure formation.
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