No abstract

Symptomatic hepatic injury develops usually within the first few months of PTU administration with rare frequency, but its clinical course is relatively benign once the drug is withdrawn. However, it may be difficult to predict its development, so all patients should be monitored for rise in LFTs at regular intervals, especially during the early period.

Although distinct growth behaviors on different faces of hexagonal ice have long been suggested, their understanding on a molecular scale has been hampered due to experimental difficulties near interfaces. We present a molecular dynamics simulation study to unravel the molecular origin of anisotropy in the growth kinetics of hexagonal ice by visualizing the formation of transient water structures in the growing ice interface. During ice growth, the formation of transient structures and their rearrangement to the final ice configuration are observed irrespective of growth direction. However, we find that their structure and duration differ significantly depending on growth direction. In the direction perpendicular to the basal face of hexagonal ice along which growth occurs most slowly, a two-dimensional transient structure, which is formed by competing hexagonal and cubic arrangements within the same layer, persists for a significant period of time, contrasted with short-lived transient structures in other directions. This observation of such transient water structures and their rearrangement during ice growth provides a clear explanation of different growth rates on each face of hexagonal ice on a molecular scale.

This paper presents a novel amplifier that satisfies both low distortion and high efficiency for high-frequency wireless ultrasound systems with limited battery life and size. While increasing the amplifier efficiency helps to address the problems for wireless ultrasound systems, it can cause signal distortion owing to harmonic components. Therefore, a new type of class F amplifier is designed to achieve high efficiency and low distortion. In the amplifier, the resonant circuit at each stage controls the harmonic components to reduce distortion and improve efficiency. Transformers with a large shunt resistor are also helpful to reduce the remaining noise in the input signal. The proposed class F amplifier is tested using simulations, and the voltage and current waveforms are analyzed to achieve correct operation with adequate efficiency and distortion. The measured performance of the class F amplifier has a gain of 23.2 dB and a power added efficiency (PAE) of 88.9% at 25 MHz. The measured DC current is 121 mA with a variance of less than 1% when the PA is operating. We measured the received echo signal through the pulse-echo response using a 25-MHz transducer owing to the compatibility of the designed class F amplifier with high- frequency transducers. The measured total harmonic distortion (THD) of the echo signal was obtained as 4.5% with a slightly low ring-down. The results show that the low THD and high PAE of the new high-efficiency and high-voltage amplifier may increase battery life and reduce the cooling fan size, thus providing a suitable environment for high-frequency wireless ultrasound systems.

Dementia, characterized by a progressive cognitive decline and a cumulative inability to behave independently, is highly associated with other diseases. Various cardiovascular disorders, such as coronary artery disease and atrial fibrillation, are well-known risk factors for dementia. Currently, increasing evidence suggests that sex factors may play an important role in the pathogenesis of diseases, including cardiovascular disease and dementia. Recent studies show that nearly two-thirds of patients diagnosed with Alzheimer’s disease are women; however, the incidence difference between men and women remains vague. Therefore, studies are needed to investigate sex-specific differences, which can help understand the pathophysiology of dementia and identify potential therapeutic targets for both sexes. In the present review, we summarize sex differences in the prevalence and incidence of dementia by subtypes. This review also describes sex differences in the risk factors of dementia and examines the impact of risk factors on the incidence of dementia in both sexes.