An optimal approach is proposed in this paper for posture reconstruction and human animation from 2D feature points extracted from the monocular images containing human motions. Biomechanical constraints are encoded in every joint of the adopted 3D skeletal human model to make sure that each state of the joints represents a physically valid posture. Size of the human model is adjusted to be consistent with the human figure represented by feature points. Energy Function is defined to represent the residuals between the extracted 2D feature points and the corresponding features resulted from projection of the 3D human model. Local Adjustment and Global Adjustment procedures are proposed to place the joints and body segments into proper locations and orientations in 3D space to create the posture with the minimum value of Energy Function. To find the optimal solution of the ill-posed recovery problem from 2D to 3D, Genetic Algorithm is employed in the high-dimensional parameter space by considering all the parameters simultaneously. Smooth and continuous changes between consecutive frames are considered in development of the human animation procedure. The proposed approach produces optimal reconstruction results of any possible human postures and movements. It is different from classical kinematics and dynamics formulations, and is an attempt to bridge the gap between computer vision and computer animation in human motion study.
Aggregation is an irreversible form of protein complexation and often toxic to cells. The process entails partial or major unfolding that is largely driven by hydration. We model the role of hydration in aggregation using "Dehydrons." "Dehydrons" are unsatisfied backbone hydrogen bonds in proteins that seek shielding from water molecules by associating with ligands or proteins. We find that the residues at aggregation interfaces have hydrated backbones, and in contrast to other forms of protein-protein interactions, are under less evolutionary pressure to be conserved. Combining evolutionary conservation of residues and extent of backbone hydration allows us to distinguish regions on proteins associated with aggregation (non-conserved dehydron-residues) from other interaction interfaces (conserved dehydron-residues). This novel feature can complement the existing strategies used to investigate protein aggregation/complexation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.