IMPORTANCE Delayed healing of diabetic foot ulcers (DFUs) is known to be caused by dysregulated M1/M2-type macrophages, and restoring the balance between these macrophage types plays a critical role in healing. However, drugs used to regulate M1/M2 macrophages have not yet been studied in large randomized clinical trials. OBJECTIVE To compare the topical application of ON101 cream with use of an absorbent dressing (Hydrofiber; ConvaTec Ltd) when treating DFUs.
The purpose of this study was to identify the minimal detectable change (MDC) of the Sollerman hand function test (SHT) for patients with burned hands. Twelve subjects were studied, giving a total of 21 burned hands (10 right hands and 11 left hands). Each subject received two sessions of SHT assessment, held at 7- to 10-day intervals. Three raters were recruited to observe and assign scores for the patients' performance during the tests. The MDC was calculated based on standard measurement error, and the intraclass correlation coefficient was applied to examine relative reliability. Results showed that both intra- and interrater MDCs were acceptable (6.7 and 6.9 points, respectively) and that both intra- and interrater relative reliabilities were excellent (intraclass correlation coefficients = 0.98). According to this study, the SHT was found to have appropriate MDC and relative reliability in monitoring changes over time for patients with burned hands. The MDCs of SHT calculated in this study are useful in determining whether any change in score is the result of more than random error.
There are currently no effective molecular targeted therapies for hepatocellular carcinoma (HCC), the third leading cause of cancer-related death worldwide. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27)-specific methyltransferase, has been emerged as novel anticancer target. Our previous study has demonstrated that GSK343, an S-adenosyl-L-methionine (SAM)-competitive inhibitor of EZH2, induces autophagy and enhances drug sensitivity in cancer cells including HCC. In this study, an in silico study was performed and found that EZH2 was overexpressed in cancerous tissues of HCC patients at both gene and protein levels. Microarray analysis and in vitro experiments indicated that the anti-HCC activity of GSK343 was associated with the induction of metallothionein (MT) genes. In addition, the negative association of EZH2 and MT1/MT2A genes in cancer cell lines and tissues was found in public gene expression database. Taken together, our findings suggest that EZH2 inhibitors could be a good therapeutic option for HCC, and induction of MT genes was associated with the anti-HCC activity of EZH2 inhibitors.
This study examined the psychometric properties of the Chinese version of the Post-traumatic Syndrome Scale-Interview (C-PSSI) for severe burn victims of the Formosa Fun Coast Explosion that occurred in Taiwan. A purposive sampling, cross-sectional, descriptive design study was selected. Participants were patients with severe burns from the Formosa Fun Coast Explosion, selected from teaching medical centers in Taiwan. They completed the C-PSSI and Patient Health Questionnaire-9 (PHQ-9). Statistical analysis was conducted to evaluate the psychometric properties, including reliability, construct validity (using confirmatory factor analysis), convergent validity, and criterion-related validity of the questionnaire. Data on 63 participants were analyzed. The Cronbach's α of the entire C-PSSI was .88, ranging from .73 to .82 for the three subscales of this instrument. The item-total correlation coefficient was from .42 to .81. Examining the convergent validity revealed that two subscores of the C-PSSI were significantly correlated with PHQ-9 total scores (ρ = .58, .44, P < .01). Criterion-related validity was confirmed because the PHQ-9 total scores were significantly correlated with the total C-PSSI scores (ρ = .54, P < .01). Confirmatory factor analysis confirmed the construct validity, with a good model fit. Integrated moderate to good psychometric properties were demonstrated and a three-factor model of the C-PSSI was verified in patients with severe burn in Taiwan. The C-PSSI exhibited adequate psychometric properties for posttraumatic stress disorder evaluation in patients with severe burn in Taiwan. The Chinese version of this scale can be used to assess the psychological problems of victims of traumatic events.
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