FeBr3‐catalyzed or LDA‐mediated S‐alkylation of thioamides followed by thio‐Claisen rearrangement allows a regio‐, diastereo‐, and enantioselective access to the title compounds.
Novel anti-β-Functionalized γ,δ-Unsaturated Amino Acids via a Thio-Claisen Rearrangement. -A significantly improved approach to novel title compounds is developed. The mild conditions allow the introduction of base-labile functional groups. -(LIU, Z.; QU, H.; GU, X.; LEE, K.-S.; GROSSMAN, B.; KUMIROV, V. K.; HRUBY*, V.
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