Liquid chromatography with amperometric detection is a rapid and sensitive method for determining commonly encountered phenolic antioxidants including 3(2)-tert-butyl-4-hydroxyanisole, tert-butylhydroquinone, n-propyl gallate, nordihydroguaiaretic acid, and 2,6-di-tert-butyl-4-hydroxymethylphenol (Ionox-100), and the antimicrobial parabens, in a variety of commercial products. Sample extracts are chromatographed directly with few interferences on the reverse phase system. The typical linear range extends from 10−11 to 10−6 mole of injected analyte. Pertinent experimental factors are discussed with regard to the requirements of the detector and optimizing the determination of this class of compounds
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