Two cobalt(II) coordination polymers, namely {[Co(HO-BDC)(bbe)]·(H 2 O)} n (1), and {[Co(O-BDC)(bbp)]·(H 2 O)} n(2) (HO-H 2 BDC = 5-hydroxyisophthalic acid, bbe = 1,2-bis(benzoimidazol-2-yl)ethane, and bbp = 1,3-bis(benzoimidazol-2-yl)propane) were synthesized under hydrothermal conditions, and characterized by elemental analyses, IR spectroscopy, single-crystal X-ray diffraction, 2091 and thermogravimetric analyses. Compound 1 is a 1D chain, whereas 2 is a (3,3)-connected 2D network with (6 3 ) topology. These two 1D and 2D complexes are further connected by hydrogen bonds to form the 3D supramolecular architectures. The electrochemical lithium-ion storage properties of the as-made Co 3 O 4 by calcination of 1 are investigated in detail.
ARTICLE
Results and Discussion
{[Co(HO-BDC)(bbe)]·(H 2 O)} n (1)Single-crystal X-ray diffraction analysis reveals that complex 1 crystallizes in the monoclinic crystal system of P2 1 /n space group. The asymmetric unit of 1 contains an independent Co II cation, one HO-BDC 2anion, one bbe ligand, and one water molecule. As shown in Figure 1, the central ion Co II is tetracoordinated by two nitrogen atoms from one bbe, and two oxygen atoms from two HO-BDC 2ligands. The presence of seven-membered ring and short Co1···O2 [2.572(2) Å] contact let the cobalt atom form a distorted tetrahedral arrangement. All coordinated bond lengths (Co-O 1.948(2) and 1.959(2) Å, Co-N 2.013(3) and 2.053(3) Å) show normal values and are comparable to those in the Co II -polycarboxylate N-donor ligand complexes.
Current prevailing knowledge on EMT (epithelial mesenchymal transition) deems epithelial cells acquire the characters of mesenchymal cells to be capable of invading and metastasizing on their own.One of the signature events of EMT is called "cadherin switch", e.g. the epithelial E-cadherin switching to the mesenchymal Cadherin-11. Here, we report the critical events after EMT that cancer cells utilize cadherin-11 to hijack the endogenous cadherin-11 positive fibroblasts. Numerous 3-D cell invasion assays with high-content live cell imaging methods reveal that cadherin-11 positive cancer cells adhere to and migrate back and forth dynamically on the cell bodies of fibroblasts. By adhering to fibroblasts for co-invasion through 3-D matrices, cancer cells acquire higher invasion speed and velocity, as well as significantly elevated invasion persistence, which are exclusive characteristics of fibroblast invasion.Silencing cadherin-11 in cancer cells or in fibroblasts, or in both, significantly decouples such physical co-invasion. Additional bioinformatics studies and PDX (patient derived xenograft) studies link such cadherin-11 mediated cancer hijacking fibroblasts to the clinical cancer progression in human such as triple-negative breast cancer patients. Further animal studies confirm cadherin-11 mediates cancer hijacking fibroblasts in vivo and promotes significant solid tumor progression and distant metastasis.Moreover, overexpression of cadherin-11 strikingly protects 4T1-luc cells from implant rejection against firefly luciferase in immunocompetent mice. Overall, our findings report and characterize the critical post-EMT event of cancer hijacking fibroblasts in cancer progression and suggest cadherin-11 can be a therapeutic target for solid tumors with stroma. Our studies hence provide significant updates on the "EMT" theory that EMT cancer cells can hijack fibroblasts to achieve full mesenchymal behaviors in vivo for efficient homing, growth, metastasis and evasion of immune surveillance. Our studies also reveal that cadherin-11 is the key molecule that helps link cancer cells to stromal fibroblasts in the "Seed & Soil" theory.
The hydrothermal reaction of the tricarboxylate ligand 5-(carboxymethoxy)isophthalic acid (H 3 L) with Zn II , Cd II , and Sn II salts in the presence of the bisbenzoimidazole coligand 1,3-bis(benzimidazol-2-yl)-2-oxapropane (bbop) afforded the coordination polymers, [Zn(HL)(bbop)] n (1), [Cd(HL)(bbop)] n (2), and {[H 2 (bbop)][Sn 2 L 2 ]} n (3). The complexes were characterized by elemental analyses, IR spectroscopy, single-crystal X-ray diffraction analyses, thermogravimetric analyses, and fluorescence properties. The
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